Objective. To identify blood biomarkers to predict severity and mortality in AIDS PCP patients. Methods. Biomarkers including\nclinical parameters and plasma inflammatory cytokines were assessed in 32 HIV-infected patients with Pneumocystis pneumonia\n(PCP) at time of admission. Predictive value of the biomarkers for clinical severity and in-hospital mortality was evaluated\nby corresponding ROC curve. Results. Levels of CRP, WBC, LDH, HBDH, and Ferritin were significantly higher in the severe\nand nonsurvivor AIDS PCP patients. These important biochemical indicators have inverse correlation with oxygenation index,\nespecially levels of LDH(P = 0.008, R2 = 0.258), HBDH(P = 0.001, R2 = 0.335), and Ferritin (P = 0.005, R2 = 0.237). Plasma IL-8\nand IL-6 levelswere significantly higher in patients with PaO2/FiO2 ââ?°Â¤ 200mmHg and nonsurvivors than in thosewith PaO2/FiO2 >\n200mmHg and survivors. Severe and nonsurvival groups showed higher ratio of mean IL-6/IL-10 level (1.78 Ã?± 1.56, P < 0.001; 1.11\nÃ?± 0.72, P = 0.043), larger AUC (95% CI 0.781ââ?¬â??1.000, P < 0.001; 95% CI 0.592ââ?¬â??0.917, P = 0.043), and more significantly inverse\ncorrelation with the oxygenation index. Conclusion. Plasma IL-8, LDH, and HBDH levels and IL-6/IL-10 ratio could be helpful for\nearly evaluation of the severity and predicting fatal outcomes in AIDS PCP patients.
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